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KMID : 0361020150580050318
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Korean Journal of Otolaryngology - Head and Neck Surgery
2015 Volume.58 No. 5 p.318 ~ p.323
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Therapeutic Effect of Zinc and Lipoprostaglandin E1 for Idiopathic Sudden Hearing Loss
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Lee Ho-Yun
Kim Ji-Chan
Chang Dong-Sik
Choi Myung-Su
Cho Chin-Saeng
Kim Ah-Young
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Abstract
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Background and Objectives: We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss.
Subjects and Method: Retrospective medical chart reviews of 500 patients who had been diagnosed with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using the data of individual patients.
Results: Better hearing gain was associated with low tone hearing loss (p<0.001), better initial contralateral hearing (p<0.001), and the absence of dizziness (p=0.015). Patients who underwent intratympanic steroid treatment as salvage treatment showed a lower hearing gain (p<0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p<0.001). On the contrary, significant improvements in hearing gain were found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p<0.001).
Conclusion: An additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for the treatment of idiopathic sudden hearing loss.
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KEYWORD
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Profound, Prostaglandin, Steroid, Sudden hearing loss
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